BWA is a fast light-weighted tool that aligns relatively short reads to a reference sequence. Click this link to open BWA homepage. BWA is embedded as an external tool into UGENE.
Open Tools ‣ DNA assembly submenu of the main menu.
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Select the Align short reads item to align short reads to a DNA sequence using BWA. Or select the Build index item to build an index for a DNA sequence which can be used to optimize aligning of short reads.